Formulation and Evaluation of Aripiprazole Oral Disintegrating Tablets

Aim: This work aims to develop oral disintegrating tablets from solid dispersion of aripiprazole that are capable enhancing solubility.
 Methodology: Aripiprazole an antipsychotic is a BCS class IV drug with Oral bioavailability 87%. To enhance the solubility this dispersions were prepared by using combination ?-Cyclodextrin and PVP K30 in 1:1, 1:2 physical mixture solvent evaporation method. The analyzed for all parameters excipient interactions. was optimized preparation direct compression technique different concentrations various natural super disintegrants namely Tapioca starch, Amorphophallus campanulactus, synthetic Sodium starch glycolate, crospovidone.
 Results: FTIR showed excipients compatible each other. Among formulations SCD6 (Drug: ?-cyclodextrin) shows high percentage release i.e., 98.58±0.28% 45 min, found be 0.954±0.32mg/ml. Percentage practical yield 98.36±0.14% content 97.31±0.04%. formulation tablets. post-compression within limits. all, F3 containing tapioca 7.5% possess better disintegration time (28±1.52sec) in-vitro dissolution (98.64±0.29% 45min).
 Conclusion: It can concluded incorporated very useful approach efficient manner.